CRK is a predicted scaffold protein, which is related to the following pathway(s).

PDGFRA->SRC->BCAR1
PDGFRA->SRC->CBL
PDGFRA->SRC->IGF1R
PDGFRA->SRC->KIT
PDGFRA->SRC->PIK3R1
PDGFRA->SRC->PLSCR1
PDGFRA->SRC->PXN
PDGFRA->SRC->RAPGEF1
PDGFRA->SRC->SHC1
PDGFRA->SRC->STAT5A
PDGFRA->SRC->STAT5B
PDGFRB->FYN->CBL
PDGFRB->FYN->SHC1
PDGFRA->SRC->ABL1->CBL
PDGFRA->SRC->ABL1->CRKL
PDGFRA->SRC->ABL1->PLSCR1
PDGFRA->SRC->EGFR->CBL
PDGFRA->SRC->EGFR->GAB1
PDGFRA->SRC->EGFR->GRB2
PDGFRA->SRC->EGFR->STAT5B
PDGFRA->SRC->PTK2->PXN



CRK is a known scaffold protein, which is related to the following pathway(s).

SRC->GAB1

Reference:Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.

PMID:19350053


CRK is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
ARHGAP17SRC->ABL1->CRK
SHC1MAPK1->EGFR->CRK
SHC1CSK->SRC->EGFR->CRK
SHC1CSK->SRC->IGF1R->CRK
SHC1SYK->PRKCA->EGFR->CRK
EGFRCSK->SRC->IGF1R->CRK
CBLCSK->SRC->EGFR->CRK
CBLPDGFRA->SRC->ABL1->CRK
CBLPDGFRA->SRC->EGFR->CRK
CBLSYK->PRKCA->EGFR->CRK
GRB2PDGFRA->SRC->ABL1->CRK
GRB2PDGFRA->SRC->EGFR->CRK
PTK2CSK->SRC->EGFR->CRK
PTK2CSK->SRC->IGF1R->CRK
STAT5BMAPK1->EGFR->CRK
STAT5BPDGFRA->SRC->EGFR->CRK
IGF1RCSK->SRC->EGFR->CRK
STAT5AMAPK1->EGFR->CRK
STAT5AMAPK3->EGFR->CRK
STAT5APDGFRA->SRC->EGFR->CRK
DOK4SRC->IGF1R->CRK
PDGFRBPDGFRA->SRC->EGFR->CRK
PXNCSK->SRC->EGFR->CRK
PXNCSK->SRC->IGF1R->CRK
INSRCSK->SRC->IGF1R->CRK
CRKPDGFRA->SRC->ABL1->CRKL
SH3BP1SRC->ABL1->CRK
KITSRC->ABL1->CRK
PIK3R1PDGFRA->SRC->ABL1->CRK
PIK3R1PDGFRA->SRC->EGFR->CRK
PIK3R1PDGFRA->SRC->IGF1R->CRK
BCAR1SRC->ABL1->CRK
BCAR1SRC->EGFR->CRK
CBLCSRC->EGFR->CRK
GAB1MAPK1->EGFR->CRK
GAB1MAPK3->EGFR->CRK
MAP4K5ABL1->CRK
VAV1RAF1->MAP2K1->MAPK1->EGFR->CRK


The sequence of CRK

Amino acids in red are phosphorylation sites determined by MS/MS

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS 50
VSENSRVSHY IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL 100
LEFYKIHYLD TTTLIEPVSR SRQGSGVILR QEEAEYVRAL FDFNGNDEED 150
LPFKKGDILR IRDKPEEQWW NAEDSEGKRG MIPVPYVEKY RPASASVSAL 200
IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA RVIQKRVPNA 250
YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 300
EDFS

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