CHEK2 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
NBNATM->CHEK2->BRCA1
MDC1ATM->CHEK2->BRCA1
MDC1ATM->CHEK2->TP53
PLK3CHEK2->CDC25C
PLK3CHEK2->TP53
CDC25CPLK1->CHEK2->TP53
RAD50ATM->CHEK2->BRCA1
ERCC6CHEK2->TP53
TP53BP1ATM->CHEK2->BRCA1
TP53BP1ATM->CHEK2->E2F1
TP53BP1ATM->CHEK2->TP53
MDM4ATM->CHEK2->E2F1
MDM4ATM->CHEK2->TP53


The sequence of CHEK2

Amino acids in red are phosphorylation sites determined by MS/MS

MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS 50
QSSHSSSGTL SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ 100
DGFANLECVN DNYWFGRDKS CEYCFDEPLL KRTDKYRTYS KKHFRIFREV 150
GPKNSYIAYI EDHSGNGTFV NTELVGKGKR RPLNNNSEIA LSLSRNKVFV 200
FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER KTCKKVAIKI 250
ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV 300
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP 350
ENVLLSSQEE DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG 400
TAGYNRAVDC WSLGVILFIC LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE 450
VWAEVSEKAL DLVKKLLVVD PKARFTTEEA LRHPWLQDED MKRKFQDLLS 500
EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA AVL 550

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