CDK7 is a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
BRCA1CDK2->CDK7->CDC2->APLP2
BRCA1CDK2->CDK7->CDC2->CSNK2B
BRCA1CDK2->CDK7->CDC2->E2F1
BRCA1CDK2->CDK7->CDC2->FANCG
BRCA1CDK2->CDK7->CDC2->PPP1CA
BRCA1CDK2->CDK7->CDK4->RBL1
BRCA1CDK2->CDK7->CDK4->RBL2
BRCA1CDK2->CDK7->CDK4->SMAD3
BRCA1CSNK2A1->CDC2->CDK7->E2F1
BRCA1CSNK2A1->CDC2->CDK7->ESR1
BRCA1CSNK2A1->CDC2->CDK7->POU2F1
BRCA1CSNK2A1->CDC2->CDK7->TP53
BRCA1CDK2->CDK7->CDC2->CSNK2A1->AKT1
BRCA1CDK2->CDK7->CDC2->CSNK2A1->HDAC1
BRCA1CDK2->CDK7->CDC2->CSNK2A1->HDAC2
BRCA1CDK2->CDK7->CDC2->CSNK2A1->IFI16
BRCA1CDK2->CDK7->CDC2->CSNK2A1->JUN
BRCA1CDK2->CDK7->CDC2->CSNK2A1->RELA
BRCA1CDK2->CDK7->CDC2->CSNK2A1->XRCC1
BRCA1CSNK2A1->CDC2->CDK7->CDK4->RBL1
BRCA1CSNK2A1->CDC2->CDK7->CDK4->RBL2
BRCA1CSNK2A1->CDC2->CDK7->CDK4->SMAD3
E2F1CDK2->CDK7->CDC2->HTATIP
CCNHCDK2->CDK7->ESR1
CCNHCDK2->CDK7->TP53
ERCC2CDC2->CDK7->TP53


The sequence of CDK7

Amino acids in red are phosphorylation sites determined by MS/MS

MALDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE 50
AKDGINRTAL REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV 100
IIKDNSLVLT PSHIKAYMLM TLQGLEYLHR HWILHRDLKP NNLLLDENGV 150
LKLADFGLAK SFGSPNRAYT HQVVTRWYRA PELLFGARMY GVGVDMWAVG 200
CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM CSLPDYVTFK 250
SFPGIPLHHI FSAAGDDLLD LIQGLFLFNP CARITATQAL KMKYFSNRPG 300
PTPGCQLPRP NCPVETLKEQ SNPALAIKRK RTEALEQGGL PKKLIF 350

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