BTK is a predicted scaffold protein, which is related to the following pathway(s).

ITK->TEC->BMX
SYK->PRKCA->KIT
SYK->PRKCA->PLCG1
SYK->PRKCA->PRKD1
SYK->PRKCA->RPS6KB2


BTK is also a signaling protein, which is involved in the following pathway(s).

Scaffold Protein(s)Related Pathway(s)
PLCG2LYN->BTK->TEC
PLCG2LYN->BTK->ITK->TEC
ARHGAP17SRC->ABL1->BTK
PLCG1LYN->BTK->TEC
PLCG1LYN->BTK->WAS
PLCG1LYN->BTK->ITK->CD28
PLCG1LYN->BTK->ITK->TEC
PLCG1PDGFRA->SRC->ABL1->BTK->TEC
PLCG1PDGFRA->SRC->ABL1->BTK->WAS
PLCG1PDGFRA->SRC->ABL1->BTK->ITK->CD28
PLCG1PDGFRA->SRC->ABL1->BTK->ITK->TEC
CBLCSK->LYN->BTK->ITK
CBLCSK->SRC->ABL1->BTK->ITK
CBLPDGFRA->SRC->ABL1->BTK->ITK
PRKD1SRC->ABL1->BTK->PLCG2
CAV1CSK->SRC->ABL1->BTK->BMX
CAV1PDGFRA->SRC->ABL1->BTK->BMX
CD19ABL1->BTK->PLCG2
CD19LYN->BTK->PLCG2
PIP5K2ABTK->TEC
DAPP1LYN->BTK->PLCG2
TECLYN->BTK->BMX
TECLYN->BTK->PLCG2
TECLYN->BTK->WAS
KITLYN->BTK->TEC
KITSRC->ABL1->BTK->TEC
BMXBTK->ITK->TEC
WASBTK->ITK->TEC
FCER1GLYN->BTK->PLCG2
KHDRBS1LYN->BTK->ITK
KHDRBS1LYN->BTK->PLCG2
RPS6KB2LYN->BTK


The sequence of BTK

Amino acids in red are phosphorylation sites determined by MS/MS

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG 50
SKKGSIDVEK ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY 100
PFQVVYDEGP LYVFSPTEEL RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG 150
QYLCCSQTAK NAMGCQILEN RNGSLKPGSS HRKTKKPLPP TPEEDQILKK 200
PLPPEPAAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE YFILEESNLP 250
WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300
EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH 350
LFSTIPELIN YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK 400
DLTFLKELGT GQFGVVKYGK WRGQYDVAIK MIKEGSMSED EFIEEAKVMM 450
NLSHEKLVQL YGVCTKQRPI FIITEYMANG CLLNYLREMR HRFQTQQLLE 500
MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF GLSRYVLDDE 550
YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600
FTNSETAEHI AQGLRLYRPH LASEKVYTIM YSCWHEKADE RPTFKILLSN 650
ILDVMDEES

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