| CDK2 | -> | CDK7 | -> | CDC2 | -> | APLP2 | CDK2 | -> | CDK7 | -> | CDC2 | -> | CSNK2B | CDK2 | -> | CDK7 | -> | CDC2 | -> | E2F1 | CDK2 | -> | CDK7 | -> | CDC2 | -> | FANCG | CDK2 | -> | CDK7 | -> | CDC2 | -> | PPP1CA | CDK2 | -> | CDK7 | -> | CDK4 | -> | RBL1 | CDK2 | -> | CDK7 | -> | CDK4 | -> | RBL2 | CDK2 | -> | CDK7 | -> | CDK4 | -> | SMAD3 | CSNK2A1 | -> | CDC2 | -> | CDK7 | -> | E2F1 | CSNK2A1 | -> | CDC2 | -> | CDK7 | -> | ESR1 | CSNK2A1 | -> | CDC2 | -> | CDK7 | -> | POU2F1 | CSNK2A1 | -> | CDC2 | -> | CDK7 | -> | TP53 | CDK2 | -> | CDK7 | -> | CDC2 | -> | CSNK2A1 | -> | AKT1 | CDK2 | -> | CDK7 | -> | CDC2 | -> | CSNK2A1 | -> | HDAC1 | CDK2 | -> | CDK7 | -> | CDC2 | -> | CSNK2A1 | -> | HDAC2 | CDK2 | -> | CDK7 | -> | CDC2 | -> | CSNK2A1 | -> | IFI16 | CDK2 | -> | CDK7 | -> | CDC2 | -> | CSNK2A1 | -> | JUN | CDK2 | -> | CDK7 | -> | CDC2 | -> | CSNK2A1 | -> | RELA | CDK2 | -> | CDK7 | -> | CDC2 | -> | CSNK2A1 | -> | XRCC1 | CSNK2A1 | -> | CDC2 | -> | CDK7 | -> | CDK4 | -> | RBL1 | CSNK2A1 | -> | CDC2 | -> | CDK7 | -> | CDK4 | -> | RBL2 | CSNK2A1 | -> | CDC2 | -> | CDK7 | -> | CDK4 | -> | SMAD3 |
| Scaffold Protein(s) | Related Pathway(s) | NBN | ATM->CHEK2->BRCA1 | MDC1 | ATM->CHEK2->BRCA1 | RAD50 | ATM->CHEK2->BRCA1 | CLSPN | ATR->BRCA1 | TP53BP1 | ATM->CHEK2->BRCA1 | DCLRE1C | ATM->BRCA1 |
|---|
The sequence of BRCA1
Amino acids in red are phosphorylation sites determined by MS/MS
MDLSALRVEE VQNVINAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK 50
LLNQKKGPSQ CPLCKNDITK RSLQESTRFS QLVEELLKII CAFQLDTGLE 100
YANSYNFAKK ENNSPEHLKD EVSIIQSMGY RNRAKRLLQS EPENPSLQET 150
SLSVQLSNLG TVRTLRTKQR IQPQKTSVYI ELGSDSSEDT VNKATYCSVG 200
DQELLQITPQ GTRDEISLDS AKKAACEFSE TDVTNTEHHQ PSNNDLNTTE 250
KRAAERHPEK YQGSSVSNLH VEPCGTNTHA SSLQHENSSL LLTKDRMNVE 300
KAEFCNKSKQ PGLARSQHNR WAGSKETCND RRTPSTEKKV DLNADPLCER 350
KEWNKQKLPC SENPRDTEDV PWITLNSSIQ KVNEWFSRSD ELLGSDDSHD 400
GESESNAKVA DVLDVLNEVD EYSGSSEKID LLASDPHEAL ICKSERVHSK 450
SVESNIEDKI FGKTYRKKAS LPNLSHVTEN LIIGAFVTEP QIIQERPLTN 500
KLKRKRRPTS GLHPEDFIKK ADLAVQKTPE MINQGTNQTE QNGQVMNITN 550
SGHENKTKGD SIQNEKNPNP IESLEKESAF KTKAEPISSS ISNMELELNI 600
HNSKAPKKNR LRRKSSTRHI HALELVVSRN LSPPNCTELQ IDSCSSSEEI 650
KKKKYNQMPV RHSRNLQLME GKEPATGAKK SNKPNEQTSK RHDSDTFPEL 700
KLTNAPGSFT KCSNTSELKE FVNPSLPREE KEEKLETVKV SNNAEDPKDL 750
MLSGERVLQT ERSVESSSIS LVPGTDYGTQ ESISLLEVST LGKAKTEPNK 800
CVSQCAAFEN PKGLIHGCSK DNRNDTEGFK YPLGHEVNHS RETSIEMEES 850
ELDAQYLQNT FKVSKRQSFA PFSNPGNAEE ECATFSAHSG SLKKQSPKVT 900
FECEQKEENQ GKNESNIKPV QTVNITAGFP VVGQKDKPVD NAKCSIKGGS 950
RFCLSSQFRG NETGLITPNK HGLLQNPYRI PPLFPIKSFV KTKCKKNLLE 1000
ENFEEHSMSP EREMGNENIP STVSTISRNN IRENVFKEAS SSNINEVGSS 1050
TNEVGSSINE IGSSDENIQA ELGRNRGPKL NAMLRLGVLQ PEVYKQSLPG 1100
SNCKHPEIKK QEYEEVVQTV NTDFSPYLIS DNLEQPMGSS HASQVCSETP 1150
DDLLDDGEIK EDTSFAENDI KESSAVFSKS VQKGELSRSP SPFTHTHLAQ 1200
GYRRGAKKLE SSEENLSSED EELPCFQHLL FGKVNNIPSQ STRHSTVATE 1250
CLSKNTEENL LSLKNSLNDC SNQVILAKAS QEHHLSEETK CSASLFSSQC 1300
SELEDLTANT NTQDPFLIGS SKQMRHQSES QGVGLSDKEL VSDDEERGTG 1350
LEENNQEEQS MDSNLGEAAS GCESETSVSE DCSGLSSQSD ILTTQQRDTM 1400
QHNLIKLQQE MAELEAVLEQ HGSQPSNSYP SIISDSSALE DLRNPEQSTS 1450
EKAVLTSQKS SEYPISQNPE GLSADKFEVS ADSSTSKNKE PGVERSSPSK 1500
CPSLDDRWYM HSCSGSLQNR NYPSQEELIK VVDVEEQQLE ESGPHDLTET 1550
SYLPRQDLEG TPYLESGISL FSDDPESDPS EDRAPESARV GNIPSSTSAL 1600
KVPQLKVAES AQSPAAAHTT DTAGYNAMEE SVSREKPELT ASTERVNKRM 1650
SMVVSGLTPE EFMLVYKFAR KHHITLTNLI TEETTHVVMK TDAEFVCERT 1700
LKYFLGIAGG KWVVSYFWVT QSIKERKMLN EHDFEVRGDV VNGRNHQGPK 1750
RARESQDRKI FRGLEICCYG PFTNMPTDQL EWMVQLCGAS VVKELSSFTL 1800
GTGVHPIVVV QPDAWTEDNG FHAIGQMCEA PVVTREWVLD SVALYQCQEL 1850
DTYLIPQIPH SHY