ARHGEF2 is a known signal protein, which is involved in the following pathway(s)

Scaffold Protein(s)Related Pathway(s)PMID
SH3RF1ARHGEF2->MAP3K11->MAP2K4->MAP2K7->MAPK812514131

Reference:POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

PMID:12514131


The sequence of ARHGEF2

Amino acids in red are phosphorylation sites determined by MS/MS

MKEAKDARYT NGHLFTTISV SGMTMCYACN KSITAKEALI CPTCNVTIHN 50
RCKDTLANCT KVKQKQQKAA LLKNNTALQS VSLRSKTTIR ERPSSAIYPS 100
DSFRQSLLGS RRGRSSLSLA KSVSTTNIAG HFNDESPLGL RRILSQSTDS 150
LNMRNRTLSV ESLIDEEVIY SELMSDFEMD EKDFAADSWS LAVDSSFLQQ 200
HKKEVMKQQD VIYELIQTEL HHVRTLKIMT RLFRTGMLEE LHLEPGVVQG 250
LFPCVDELSD IHTRFLSQLL ERRRQALCPG STRNFVIHRL GDLLISQFSG 300
PSAEQMCKTY SEFCSRHSKA LKLYKELYAR DKRFQQFIRK VTRPAVLKRH 350
GVQECILLVT QRITKYPLLI SRILQHSHGI EEERQDLTTA LGLVKELLSN 400
VDEGIYQLEK GARLQEIYNR MDPRAQTPVP GKGPFGREEL LRRKLIHDGC 450
LLWKTATGRF KDVLVLLMTD VLVFLQEKDQ KYIFPTLDKP SVVSLQNLIV 500
RDIANQEKGM FLISAAPPEM YEVHTASRDD RSTWIRVIQQ SVRTCPSRED 550
FPLIETEDEA YLRRIKMELQ QKDRALVELL REKVGLFAEM THFQAEEDGG 600
SGMALPTLPR GLFRSESLES PRGERLLQDA IREVEGLKDL LVGPGVELLL 650
TPREPALPLE PDSGGNTSPG VTANGEARTF NGSIELCRAD SDSSQRDRNG 700
NQLRSPQEEA LQRLVNLYGL LHGLQAAVAQ QDTLMEARFP EGPERREKLC 750
RANSRDGEAG RAGAAPVAPE KQATELALLQ RQHALLQEEL RRCRRLGEER 800
ATEAGSLEAR LRESEQARAL LEREAEEARR QLAALGQTEP LPAEAPWARR 850
PVDPRRRSLP AGDALYLSFN PPQPSRGTDR LDLPVTTRSV HRNFEDRERQ 900
ELGSPEERLQ DSSDPDTGSE EEGSSRLSPP HSPRDFTRMQ DIPEETESRD 950
GEAVASES

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